基本資料 / Profiles
廖柏翔 助理研究員
Po-Hsiang Liao, Assistant Research Fellow
藥物研發中心助理研究員
職稱 / Job Title
藥物研發中心 助理研究員
Assistant Research Fellow, Center for Drug Research and Development
經歷 / Experience
- 花蓮慈濟醫學中心 外泌體暨粒線體疾病研究中心 助理研究員
- 衛生福利部雙和醫院 一般外科 醫學研究員
- 中國醫藥大學附設醫院 外泌體暨粒線體疾病醫學研究中心 助理研究員
主要學歷 / Education
中國醫藥大學 基礎醫學研究所 博士
Ph.D., Institute of Basic Medical Sciences, China Medical University
研究專長 / Research Specialization
分子醫學、癌症抗藥性、代謝與老化相關疾病
Molecular Medicine, Cancer Drug Resistance, Metabolism and Aging-related Diseases
實驗室成員與位置 / Lab Members & Location
成員團隊：
- 研究助理 (Research Assistants)：2 人
- 大學部專題生 (Undergraduate Students)：2 人
實驗室位置：
E棟4樓 分子醫學研究室
Laboratory of Molecular Medicine, Building E, 4th Floor
研究方向 / Research Focus
- 癌症抗藥性分子機轉探討：深入研究腫瘤細胞面對藥物時的逃逸與耐藥機制。
(Molecular mechanisms of cancer drug resistance) - 代謝性與老化相關疾病機轉探討：著重於老齡化社會下，慢性代謝疾病的細胞分子病理基礎。
(Mechanisms of metabolic and aging-related diseases) - 中草藥/天然物與單一成分應用評估：自天然植物中篩選活性小分子，進行功能性與治療潛力驗證。
(Evaluation of herbal medicines, natural compounds, and their active constituents) - 健康食品開發與評估：連結基礎實驗數據，研發兼具科學實證與保健功效的生技食品。
(Development and evaluation of health foods)
論文著作 (近五年內著作目錄) / Publications (Selected Papers)
- Hsu TW, Wang WY, Chen A, Chiu CF, , Chen HA, Su CM, Tsai KY, Wang TH and Su YH. (2024, Aug). Nrf2-mediated ADSL promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma cells through ferroptosis escape. Journal of Cellular Physiology.
- Ho TJ, Tamilselvi Shanmugam, , Shibu MA, Chen ST, Lin KH, Lu SY, Kuo CH, Kuo WW and Huang CY. (2024, May). Renal protective effects of Alpinate Oxyphyllae Fructus and mesenchymal stem cells co-treatment against D-galactose induced renal deterioration. International Journal of Medical Science, 21(8):1491-1499.
- Chiu CH, Lin YJ, Ramesh S, Kuo WW, Chen MC, Kuo CH, Li CC, Wang TF, Lin YM, , Huang CY (2023, Aug). Gemcitabine resistance in non-small cell lung cancer is mediated through activation of the PI3K/AKT/NF-κB pathway and suppression of ERK signaling by reactive oxygen species. Journal of Biochemical and Molecular Toxicology, e23497.
- Chiu CH, Ramesh S, , Kuo WW, Chen MC, Kuo CH, Li CC, Wang TF, Lin YM, Lin YJ and Huang CY (2023, Sep). Phosphorylation of Bcl-2 by JNK confers gemcitabine resistance in lung cancer cells by reducing autophagy-mediated cell death. Environmental Toxicology, 38(9):2121-2131.
- Hsu TW, Su YH, Chen HA, , Shen SC, Tsai KY, Wang TH, Chen A, Huang CY, Shibu MA, Wang WY, Shen SC (2023, Jul). Galectin-1-mediated MET/AXL signaling enhances sorafenib resistance in hepatocellular carcinoma by escaping ferroptosis. Aging (Albany NY), 15(13):6503-6525.
- Su CM, Hsu TW, Chen HA, Wang WY, Huang CY, Huang CC, Yeh MH, Su YH, Huang MT and (2023, Apr). Chaperone-mediated autophagy degrade Dicer to promote breast cancer metastasis. Journal of Cellular Physiology, 238(4):829-841.
- Lee TK, Ashok Kumar K, Huang CY, , Ho TJ, Kuo WW, Liao SC, Hsieh DJ, Chiu PL, Chang YM, Ju DT (2023, Mar). Garcinol protects SH-SY5Y cells against MPP+-induced cell death by activating DJ-1/SIRT1 and PGC-1α mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy. Environmental Toxicology, 38(4):857-866.
- Hsu TW, Chen HA, , Su YH, Chiu CF, Huang CY, Lin YJ, Hung CC, Yeh MH, Sung SY, Su CM (2022, Aug). Dicer-mediated miR-200b expression contributes to cell migratory/invasive abilities and cancer stem cells properties of breast cancer cells. Aging (Albany NY), 14(16):6520-6536.
- Liu YS, Chang YC, Kuo WW, Chen MC, Wang TF, Chen TS, Lin YM, Li CC, and Huang CY* (2022, Jun). Calreticulin nuclear translocalization alleviates CaM/CaMKII/CREB signaling pathway to enhance chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells. Aging (Albany NY), 14(12):5097-5115.
- Su CM, Hsu TW, Sung SY, Huang MT, Chen KC, Huang CY, Chiang CY, Su YH, Chen HA and (2021, Jul). AXL is crucial for E1A-enhanced therapeutic efficiency of EGFR tyrosine kinase inhibitors through NFI in breast cancer. Environmental Toxicology, 36(7):1278-1287.
- Chen HA, Li CC, Lin YJ, Wang TF, Chen MC, Su YH, Yeh YL, Padma VV, and Huang CY* (2021, Apr). Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells. Aging (Albany NY), 13(8):12046-12057.
- Chang YM, Manoj Kumar M, Lu CY, Te Tsai C, Tsai CC, , Lin SL, Chang CC, Mahalakshmi B, Kuo WW, Huang CY. (2020, Sep). Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life Sciences, 257:118019.
- Hsieh JY, Marte L, Kuo WW, Ju DT, Chen ST, Kuo CH, Day H, Mahalakshmi B, and Huang CY* (2020, Jul). Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain. International Journal of Medical Sciences, 17(13):1916-1926.
- Huang CY, Sivalingam K, Shibu MA, , Ho TJ, Kuo WW, Chen RJ, Day H, Viswanadha VP and Ju DT (2020, Jun). Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels. Nutrients, 12(6):1707.
- Chang YM, Ashok Kumar K, Ju DT, Ho TJ, Mahalakshmi B, Lin WT, Day CH, Vijaya PV, , Huang CY (2020, May). Dipeptide IF prevents the effects of hypertension-induced Alzheimer's disease on long-term memory in the cortex of spontaneously hypertensive rats. Environmental Toxicology.