1. 免疫調控與抗病毒劑(Immunomodulators and anti-viral agents)
2. 電腦輔助藥物設計(Computer-assisted drug design)

1. Wen-Fang Tang, Hui-Ping Tsai, Yuan-Fan Chin, Shan-Ko Tsai, Cheng-Chin Lin, Son Tung Ngo, Po-Huang Liang, Jia-Rong Jheng, Chung-Fan Hsieh, Jin-Ching Lee, Yu-Hsiu Chang, Tein-Yao Chang, Chia-Yi Lin, Guan-Hua Lin, Jie-Yun Cai, Yu-Li Chen, Yuan-Siao Chen, Ping-Cheng Liu, Chuen-Mi Yang, Tolou Shadbahr,
   Jim-Tong Horng. Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies. Biomed. Pharmacother. 2025, 189, 118052. DOI:10.1016/j.biopha.2025.118252
2. Kateryna Uminska, Michal Korinek, Liudas Ivanauskas, Mohamed El-Shazly, Victoriya Georgiyants, Yu-Li Chen, Monu Kumar Shukla, Sedin Renadi, Tsong-Long Hwang, Fang-Rong Chang, Olha Mykhailenko. Assessment of the phenolics content in Epilobium angustifolium and Epilobium hirsutum extracts and their pharmacological activity. Arch. Pharm. (Weinheim), 2025, 358(5), e12001. DOI: 10.1002/ardp.202400765
3. Kuan-Ting Chuang, Siao-Cian Pan, Bor-Luen Chiang, Shih-Hsun Chen, Min-Hsiung Pan, Yu-Li Chen, Cheng-Sheng Lin, Chun-Kai Pan, Jing-Yi Lin, Yu-Li Lin. Pterostilbene exhibits broad-spectrum antiviral activity by targeting the enterovirus capsid, inactivating viral particles, blocking viral binding, and protecting mice from lethal EV-A71 challenge. Phytother. Res. 2025, 39(6), 2672-2688. DOI: 10.1002/ptr.8496
4. Po-Jen Chen, Shun-Hua Chen, Yu-Li Chen, Yi-Hsuan Wange, Cheng-Yu Lin, Chun-Hong Chen,Yung-Fong Tsai, Tsong-Long Hwang*. Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. J. Adv. Res. 2024, 62, 229-243. DOI: 10.1016/j.jare.2024.03.019
5. Yu-Li Chen, Pei-Yu Chao, Chung-Fan Hsieh, Pei-Wen Hsieh, Jim-Tong Horng*. Novel anti-viral properties of the herbal extract of Davallia mariesii against influenza A virus. Viruses 2024, 16(4), 523. DOI: 10.3390/v16040523
6. Wen-Fang Tang, Yu-Hsiu Chang, Cheng-Chin Lin, Jia-Rong Jheng, Chung-Fan Hsieh, Yuan-Fan Chin, Tein-Yao Chang, Jin-Ching Lee, Po-Huang Liang, Chia-Yi Lin, Guan-Hua Lin, Jie-Yun Cai, Yu-Li Chen, Yuan-Siao Chen, Shan-Ko Tsai, Ping-Cheng Liu, Chuen-Mi Yang, Tolou Shadbahr, Jing Tang, Yu-Lin Hsu, Chih-Heng Huang, Ling-Yu Wang, Cheng Cheung Chen, Jyh-Hwa Kau, Yi-Jen Hung, Hsin-Yi Lee, Wen-Chieh Wang, Hui-Ping Tsai, Jim-Tong Horng*. BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. Antimicrob. Agents Chemother. 2024, 68(4), e0095623. DOI: 10.1128/aac.00956-23
7. Zheng-Zhe, Tsai Su-Ying Chien, Chih-Kai Hsu, Po-Jen Chen, Zhi-Hong Wen, Yu-Li Chen, Ping-Jyun Sung, Kuei-Hung Lai* and Hsu-Ming Chung*. A new sterol-related metabolite from the soft coral Capnella imbricata. Rec. Nat Prod. 2024, 3,357-362. DOI: 10.25135/rnp.455.2402.3141
8. Ting-Yu Cheng, Chia-Jung Yang, Po-Jen Chen, Yu-Li Chen, Bo-Rong Peng, Te-An Kung, Zhi-Hong Wen, Kuei-Hung Lai*, Hsu-Ming Chung*. Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata. Phytochem. Lett. 2024, 61, 115-119. DOI: 10.1016/j.phytol.2024.03.015
9. Yu-Li Chen, Chun-Yu Chen, Kuei-Hung Lai, Yu-Chia Chang, Tsong-Long Hwang*. Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19. J. Funct. Food. 2023, 101, 105407. DOI: 10.1016/j.jff.2023.105407
10. Chien-Chiao Wang, Yu-Li Chen, Ta-Chien Lu, Catherine Lee, Yu-Chia Chang, Yen-Fan Chan, Philip Mathew, Xing-Rong Lin, Wen-Rung Hsieh, Ting-Yun Huang, Hsin-Lan Huang, Tsong-Long Hwang*. Design and evaluation of oral formulation for apixaban. Heliyon 2023, 9(8), e18422. DOI: 10.1016/j.heliyon.2023.e18422
11. Shaimaa Fayez, Mariam I. Gamal El-Din1, Saad A. Moghannem, Faizul Azam, Mohamed El-Shazly*, Michal Korinek, Yu-Li Chen, Tsong-Long Hwang* and Nouran M. Fahmy. Eucalyptus-derived essential oils alleviate microbes and modulate inflammation by suppressing superoxide and elastase release. Front. Pharmacol. 2023, 14, 1218315. DOI: 10.3389/fphar.2023.1218315
12. Chung-Fan Hsieh , Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, and Jim-Tong Horng*. 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 2022, 96(7), e0054221. DOI: 10.1128/jvi.00542-21
13. Kuei-Hung Lai*, Yu-Li Chen, Mei-Fang Lin, Mohamed El-Shazly, Yu-Chia Chang, Po-Jen Chen, Chun-Han Su, Yen-Chun Chiu, Amina M. Illias, Chih-Chuan Chen, Lo-Yun Chenand, and Tsong-Long Hwang*. Lonicerae japonicae Flos attenuates neutrophilic inflammation by inhibiting oxidative stress. Antioxidants 2022, 11(9), 1781. DOI: 10.3390/antiox11091781
14. Yen-Tung Lee, Yu-Li Chen, Yi-Hsuan Wu, Ih-Sheng Chen, Hsun-Shuo Chang, Yi-Hsuan Wang, Shih-Hsin Chang, Yi-Hsiu Wu, Ting-I Kao, Huang-Ping Yu*, and Tsong-Long Hwang*. meso-Dihydroguaiaretic acid ameliorates acute respiratory distress syndrome through inhibiting neutrophilic inflammation and scavenging free radical. Antioxidants 2022, 11(1), 123. DOI: 10.3390/antiox11010123
15. Chun‐Han Su, Yu‐Chieh Cheng, Yu‐Chia Chang, Ting‐Hsuan Kung, Yu‐Li Chen, Kuei‐Hung Lai, Hsi‐Lung Hsieh, Chun‐Yu Chen*, Tsong‐Long Hwang*, and Yu‐Liang Yang*. Untargeted LC‐MS/MS‐based
    multi‐informative molecular networking for targeting the antiproliferative ingredients in Tetradium ruticarpum Fruit. Molecules 2022, 27(14), 4462. DOI: 10.3390/molecules27144462
16. Wei-Jen Cheng, Hsuan-Tzu Yang, Chih-Chao Chiang, Kuei-Hung Lai, Yu-Li Chen, Huei-Lin Shih, Jong-Jen Kuo*, Tsong-Long Hwang*, and Chi-Chien Lin*. Deer velvet antler extracts exert anti-inflammatory and anti-arthritic effects on human rheumatoid arthritis fibroblast-like synoviocytes and distinct mouse arthritis. Am. J. Chin. Med. 2022, 50(6), 1-27. DOI: 10.1142/S0192415X22500689
17. Kung-Ju Chen, Yu-Li Chen, Shir-Hwa Ueng, Tsong-Long Hwang, Liang-Mou Kuo, and Pei-Wen Hsieh*. Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis. Biomed. Pharmacother. 2021, 134, 111152. DOI: 10.1016/j.biopha.2020.111152
18. Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, and Tsong-Long Hwang*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharm. 2021, 190, 114596. DOI:
    10.1016/j.bcp.2021.114596
19. Wei-Jen Cheng, Chih-Chao Chiang, Cheng-Yu Lin, Yu-Li Chen, Yann-Lii Leu, Jia-Yu Sie, Wen-Ling Chen, Chung-Yuan Hsu, Jong-Jen Kuo*, and Tsong-Long Hwang*. Astragalus mongholicus Bunge water extract exhibits anti-inflammatory effects in human neutrophils and alleviates Imiquimod-Induced Psoriasis-Like
    Skin Inflammation in Mice. Front. Pharmacol. 2021, 12, 762829. DOI: 10.3389/fphar.2021.762829
20. Wen-Fang Tang, Hui-Ping Tsai, Yu-Hsiu Chang, Tein-Yao Chang, Chung-Fan Hsieh, Chia-Yi Lin, Guan-Hua Lin, Yu-Li Chen, Jia-Rong Jheng, Ping-Cheng Liu, Chuen-Mi Yang, Yuan-Fan Chin, Cheng Cheung Chen, Jyh-Hwa Kau, Yi-Jen Hung, Po-Shiuan Hsieh, and Jim-Tong Horng*. Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation. Biomed. J. 2021, 44(3), 293-303. DOI: 10.1016/j.bj.2021.01.005

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