基本資料 / Profiles
陳俞利 助理研究員
Yu Li Chen, Assistant Research Fellow
藥物研發中心助理研究員
現職 / Job Title
藥物研發中心 助理研究員
Assistant Research Fellow, Center for Drug Research and Development
經歷 / Experience
- 長庚科技大學 藥物研發中心 助理研究員
主要學歷 / Education
長庚大學 生物醫學研究所 博士
Ph.D., Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan
研究專長 / Research Specialization
新藥開發、天然物化學、分析化學
Drug Development, Natural Products Chemistry, Analytical Chemistry
實驗室成員與位置 / Lab Members & Location
實驗室位置：
E棟4樓
研究方向 / Research Focus
- 免疫調控與抗病毒劑：專注於尋找具備免疫調節與對抗病毒活性之新興有效成分。
(Immunomodulators and anti-viral agents) - 電腦輔助藥物設計：利用計算生物學與電腦精準模擬，加速小分子藥物的開發與篩選流程。
(Computer-assisted drug design)
論文著作 (近五年內著作目錄) / Publications (Selected Papers)
- Tang, Wen-Fang; Tsai, Hui-Ping; Chin, Yuan-Fan; Tsai, Shan-Ko; Lin, Cheng-Chin; Ngo, Son Tung; Liang, Po-Huang; Jheng, Jia-Rong; Hsieh, Chung-Fan; Lee, Jin-Ching; Chang, Yu-Hsiu; Chang, Tein-Yao; Lin, Chia-Yi; Lin, Guan-Hua; Cai, Jie-Yun; ; Chen, Yuan-Siao; Liu, Ping-Cheng; Yang, Chuen-Mi; Shadbahr, Tolou; Horng, Jim-Tong. (2025) Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies. Biomed. Pharmacother. 189, 118052. DOI:10.1016/j.biopha.2025.118252
- Uminska, Kateryna; Korinek, Michal; Ivanauskas, Liudas; El-Shazly, Mohamed; Georgiyants, Victoriya; ; Shukla, Monu Kumar; Renadi, Sedin; Hwang, Tsong-Long; Chang, Fang-Rong; Mykhailenko, Olha. (2025) Assessment of the phenolics content in Epilobium angustifolium and Epilobium hirsutum extracts and their pharmacological activity. Arch. Pharm. (Weinheim), 358(5), e12001. DOI: 10.1002/ardp.202400765
- Chuang, Kuan-Ting; Pan, Siao-Cian; Chiang, Bor-Luen; Chen, Shih-Hsun; Pan, Min-Hsiung; ; Lin, Cheng-Sheng; Pan, Chun-Kai; Lin, Jing-Yi; Lin, Yu-Li. (2025) Pterostilbene exhibits broad-spectrum antiviral activity by targeting the enterovirus capsid, inactivating viral particles, blocking viral binding, and protecting mice from lethal EV-A71 challenge. Phytother. Res. 39(6), 2672-2688. DOI: 10.1002/ptr.8496
- Chen, Po-Jen; Chen, Shun-Hua; ; Wange, Yi-Hsuan; Lin, Cheng-Yu; Chen, Chun-Hong; Tsai, Yung-Fong; Hwang, Tsong-Long*. (2024) Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. J. Adv. Res. 62, 229-243. DOI: 10.1016/j.jare.2024.03.019
- ; Chao, Pei-Yu; Hsieh, Chung-Fan; Hsieh, Pei-Wen; Horng, Jim-Tong*. (2024) Novel anti-viral properties of the herbal extract of Davallia mariesii against influenza A virus. Viruses 16(4), 523. DOI: 10.3390/v16040523
- Tang, Wen-Fang; Chang, Yu-Hsiu; Lin, Cheng-Chin; Jheng, Jia-Rong; Hsieh, Chung-Fan; Chin, Yuan-Fan; Chang, Tein-Yao; Lee, Jin-Ching; Liang, Po-Huang; Lin, Chia-Yi; Lin, Guan-Hua; Cai, Jie-Yun; ; Chen, Yuan-Siao; Tsai, Shan-Ko; Liu, Ping-Cheng; Yang, Chuen-Mi; Shadbahr, Tolou; Tang, Jing; Hsu, Yu-Lin; Huang, Chih-Heng; Wang, Ling-Yu; Chen, Cheng Cheung; Kau, Jyh-Hwa; Hung, Yi-Jen; Lee, Hsin-Yi; Wang, Wen-Chieh; Tsai, Hui-Ping; Horng, Jim-Tong*. (2024) BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. Antimicrob. Agents Chemother. 68(4), e0095623. DOI: 10.1128/aac.00956-23
- Tsai, Zheng-Zhe; Chien, Su-Ying; Hsu, Chih-Kai; Chen, Po-Jen; Wen, Zhi-Hong; ; Sung, Ping-Jyun; Lai, Kuei-Hung* and Chung, Hsu-Ming*. (2024) A new sterol-related metabolite from the soft coral Capnella imbricata. Rec. Nat Prod. 3,357-362. DOI: 10.25135/rnp.455.2402.3141
- Cheng, Ting-Yu; Yang, Chia-Jung; Chen, Po-Jen; ; Peng, Bo-Rong; Kung, Te-An; Wen, Zhi-Hong; Lai, Kuei-Hung*, Chung, Hsu-Ming*. (2024) Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata. Phytochem. Lett. 61, 115-119. DOI: 10.1016/j.phytol.2024.03.015
- ; Chen, Chun-Yu; Lai, Kuei-Hung; Chang, Yu-Chia; Hwang, Tsong-Long*. (2023) Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19. J. Funct. Food. 101, 105407. DOI: 10.1016/j.jff.2023.105407
- Wang, Chien-Chiao; ; Lu, Ta-Chien; Lee, Catherine; Chang, Yu-Chia; Chan, Yen-Fan; Mathew, Philip; Lin, Xing-Rong; Hsieh, Wen-Rung; Huang, Ting-Yun; Huang, Hsin-Lan; Hwang, Tsong-Long*. (2023) Design and evaluation of oral formulation for apixaban. Heliyon 9(8), e18422. DOI: 10.1016/j.heliyon.2023.e18422
- Fayez, Shaimaa; El-Din1, Mariam I. Gamal; Moghannem, Saad A.; Azam, Faizul; El-Shazly, Mohamed*; Korinek, Michal; ; Hwang, Tsong-Long* and Fahmy, Nouran M. (2023) Eucalyptus-derived essential oils alleviate microbes and modulate inflammation by suppressing superoxide and elastase release. Front. Pharmacol. 14, 1218315. DOI: 10.3389/fphar.2023.1218315
- Hsieh, Chung-Fan; ; Lin, Guan-Hua; Chan, Yoke Fun; Hsieh, Pei-Wen; and Horng, Jim-Tong*. (2022) 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 96(7), e0054221. DOI: 10.1128/jvi.00542-21
- Lai, Kuei-Hung*; ; Lin, Mei-Fang; El-Shazly, Mohamed; Chang, Yu-Chia; Chen, Po-Jen; Su, Chun-Han; Chiu, Yen-Chun; Illias, Amina M.; Chen, Chih-Chuan; Chenand, Lo-Yun; and Hwang, Tsong-Long*. (2022) Loniceraae japonicae Flos attenuates neutrophilic inflammation by inhibiting oxidative stress. Antioxidants 11(9), 1781. DOI: 10.3390/antiox11091781
- Lee, Yen-Tung; ; Wu, Yi-Hsuan; Chen, Ih-Sheng; Chang, Hsun-Shuo; Wang, Yi-Hsuan; Chang, Shih-Hsin; Wu, Yi-Hsiu; Kao, Ting-I; Yu, Huang-Ping*, and Hwang, Tsong-Long*. (2022) meso-Dihydroguaiaretic acid ameliorates acute respiratory distress syndrome through inhibiting neutrophilic inflammation and scavenging free radical. Antioxidants 11(1), 123. DOI: 10.3390/antiox11010123
- Su, Chun‐Han; Cheng, Yu‐Chieh; Chang, Yu‐Chia; Kung, Ting‐Hsuan; ; Lai, Kuei‐Hung; Hsieh, Hsi‐Lung; Chen, Chun‐Yu*; Hwang, Tsong‐Long*, and Yang, Yu‐Liang*. (2022) Untargeted LC‐MS/MS‐based multi‐informative molecular networking for targeting the antiproliferative ingredients in Tetradium ruticarpum Fruit. Molecules 27(14), 4462. DOI: 10.3390/molecules27144462
- Cheng, Wei-Jen; Yang, Hsuan-Tzu; Chiang, Chih-Chao; Lai, Kuei-Hung; ; Shih, Huei-Lin; Kuo, Jong-Jen*; Hwang, Tsong-Long*, and Lin, Chi-Chien*. (2022) Deer velvet antler extracts exert anti-inflammatory and anti-arthritic effects on human rheumatoid arthritis fibroblast-like synoviocytes and distinct mouse arthritis. Am. J. Chin. Med. 50(6), 1-27. DOI: 10.1142/S0192415X22500689
- Chen, Kung-Ju; ; Ueng, Shir-Hwa; Hwang, Tsong-Long; Liang, Mou Kuo; and Hsieh, Pei-Wen*. (2021) Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis. Biomed. Pharmacother. 134, 111152. DOI: 10.1016/j.biopha.2020.111152
- Korinek, Michal; Hsieh, Pei-Shan; ; Hsieh, Pei-Wen; Chang, Shih-Hsin; Wu, Yi-Hsiu; and Hwang, Tsong-Long*. (2021) Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharm. 190, 114596. DOI: 10.1016/j.bcp.2021.114596
- Cheng, Wei-Jen; Chiang, Chih-Chao; Lin, Cheng-Yu; ; Leu, Yann-Lii; Sie, Jia-Yu; Chen, Wen-Ling; Hsu, Chung-Yuan; Kuo, Jong-Jen*; and Hwang, Tsong-Long*. (2021) Astragalus mongholicus Bunge water extract exhibits anti-inflammatory effects in human neutrophils and alleviates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Front. Pharmacol. 12, 762829. DOI: 10.3389/fphar.2021.762829
- Tang, Wen-Fang; Tsai, Hui-Ping; Chang, Yu-Hsiu; Chang, Tein-Yao; Hsieh, Chung-Fan; Lin, Chia-Yi; Lin, Guan-Hua; ; Jheng, Jia-Rong; Liu, Ping-Cheng; Yang, Chuen-Mi; Chin, Yuan-Fan; Chen, Cheng Cheung; Kau, Jyh-Hwa; Hung, Yi-Jen; Hsieh, Po-Shiuan; and Horng, Jim-Tong*. (2021) Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation. Biomed. J. 44(3), 293-303. DOI: 10.1016/j.bj.2021.01.005