基本資料 / Profiles
龎浩翰 助理研究員
Hao-Han Pang, Assistant Research Fellow
藥物研發中心助理研究員
現職 / Job Title
藥物研發中心 助理研究員
Assistant Research Fellow, Center for Drug Research and Development
經歷 / Experience
- 長庚科技大學 藥物研發中心 助理研究員
- 美國俄亥俄州立大學 訪問學者
- 美國全國兒童醫院 博士後研究員
- 國立成功大學 生物醫學工程學系 博士後研究員
- 國立中山大學 醫學科技研究所 博士後研究員
主要學歷 / Education
國立中山大學 生物醫學研究所 博士
Ph.D., Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
研究專長 / Research Specialization
奈米生醫材料、基因治療與藥物輸送、分子模擬、基因工程、腦癌分子生物機轉
Nano-biomaterials, gene therapy and drug delivery, molecular simulation, genetic engineering, brain tumor molecular mechanisms.
實驗室成員與位置 / Lab Members & Location
成員配置：
- 研究助理 (Research Assistants)：1 人
實驗室位置：
E棟4樓 藥物設計與劑型創新應用研究室
研究方向 / Research Focus
- 奈米藥物或基因治療輸送載體開發：開發基於生物材料之奈米載體應用於藥物輸送與基因治療輸送等領域。
(Nanocarrier Development: Developing nanobiomaterial carriers for applications in drug delivery and gene delivery.) - 分子模擬與蛋白質結構預測：利用分子模擬與蛋白質結構預測技術開發功能性重組蛋白，應用於蛋白藥物或開發輸送載體。
(Molecular simulation and protein structure prediction: Use molecular simulation and protein structure prediction to develop functional recombinant proteins for applications in protein drugs or development of delivery vectors.) - 重組蛋白設計與基因工程：設計功能性重組蛋白並利用基因工程技術生產、萃取與純化重組蛋白，並利用工程化奈米載體應用於生醫相關應用。
(Recombinant protein design and genetic engineering: Design functional recombinant proteins and utilize genetic engineering technology to produce, extract and purify recombinant proteins. Development of engineered nanocarriers for biomedical applications.) - 腦癌分子生物機轉：研究腦癌細胞分子生物學機轉，並開發為潛在治療靶點。
(Molecular Biological Mechanism of Brain tumors: Study the molecular biological mechanism of brain tumor cells and develop potential therapeutic targets.)
論文著作 (近五年內著作目錄) / Publications (Selected Papers)
- Pan, Yu-Chi; Chen, Ying-Tzu; ; Prayadrat, Chatchayapa; Huang, ShihChung; Yang, Hung-Wei. (2025) RNA aptamer-packaged virus-like particles for label-free, rapid, and on-site fluorescence detection of malachite green in aquatic products. Biosensors and Bioelectronics 228, 117796. 10.1016/j.bios.2025.117796.
- Hsu, Ying-Pei; Li, Nan-Si; ; Pan, Yu-Chi; Tsai, Hung-Pei; Chen, HsiaoChien; Chen, Ying-Tzu; Weng, Chen-Hsun; Kuo, Shiao-Wei; Yang, Hung-Wei. (2025) Lab-on-the-Needles: A Microneedle Patch-Based Mobile Unit for Highly Sensitive Ex Vivo and In Vivo Detection of Protein Biomarkers. ACS nano 19, 3249–3264. DOI: 10.1021/acsnano.4c11238. (Journal Cover)
- Li, Nan-Si; Hsu, Ying-Pei; ; Wang, Sheng-Fan; Pang, See-Tong; Lin, Chih-Yen; Tsai, Rung-Ywan; Huang, Chiung-Yin; Wei, Kuo-Chen; Yang, Hung-Wei. (2024) Lab-in-a-Vial Rapid Test for Internet of Things Imbedded Point-of-Healthcare Protein Biomarker Detections in Bodily Fluids. Small 20, 2470369. DOI: 10.1002/smll.202400878 (Journal Cover)
- ; Li, Nan-Si; Hsu, Ying-Pei; Ju, Shin-Pon; Syu, Guan-Da; Du, Pin-Xian; Huang, Chiung-Yin; Wei, Kuo-Chen; Yang, Hung-Wei (2024) AI-Driven Design System for Fabrication of Inhalable Nanocatchers for Virus Capture and Neutralization. Advanced Healthcare Materials 13, 2302927. DOI: 10.1002/adhm.202302927. (Journal Cover)
- ; Chiung-Yin Huang; Pin-Yuan Chen; Nan-Si Li; Ying-Pei Hsu; Jan-Kai Wu; Hsiu-Fang Fan; Wei, Kuo-Chen*; and Yang, Hung-Wei*. (2023) Bioengineered bacteriophage-like nanoparticles as RNAi therapeutics to enhance radiotherapy against glioblastomas. ACS Nano 17, 10407–10422. DOI: 10.1021/acsnano.3c01102. (Journal Cover)
- Chen, Yi-Jyun; Hsu, Ying-Pei; Tain, You-Lin; Li, Nan-Si; ; Kuo, ShiaoWei*; Yang, Hung-Wei* (2022) Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic. Biosensors and Bioelectronics 208, 114234. DOI: 10.1016/j.bios.2022.114234.
- Chen, Wen-Hsuan; Yu, Kai-Jie; Jhou, Jia-Wei; ; Weng, Wen-Hui; Lin, Wen-Sou*; and Yang, Hung-Wei* (2021) Glucose/glutathione co-triggered tumour hypoxia relief and chemodynamic therapy to enhance photothermal therapy in bladder cancer. ACS Applied Bio Materials, 4, 10, 7485–7496. DOI: 10.1021/acsabm.1c00741.
- ; Ke, Yong-Chen; Li, Nan-Si; Chen, Ying-Tzu; Huang, Chiung-Yin; Wei, Kuo-Chen*; Yang, Hung-Wei*. (2020) A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level. Biosensors and Bioelectronics 165, 112325. DOI: 10.1016/j.bios.2020.112325
- Li, Nan-Si; Chen, Ying-Tzu; Hsu, Ying-Pei; ; Huang, Chiung-Yin; Shiue, Yow-Ling; Wei, Kuo-Chen*; Yang, Hung-Wei* (2020) Mobile healthcare system based on the combination of lateral flow pad and smartphone for rapid detection of uric acid detection in whole blood. Biosensors and Bioelectronics 164, 112309. DOI: doi.org/10.1016/j.bios.2020.112309.
- Hsu, Ying-Pei; Yang, Hung-Wei*; Li, Nan-Si; Chen, Ying-Tzu; ; and Pang, See-Tong. (2020) Instrument-Free Detection of FXYD3 Using Vial-Based Immunosensor for Earlier and Faster Urothelial Carcinoma Diagnosis. ACS Sensors 5, 928-935. DOI: 10.1021/acssensors.9b02013.
- Hsu, Ying-Pei; Li, Nan-Si; Chen, Ying-Tzu; ; Wei, Kuo-Chen; Yang, Hung-Wei* (2020) A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone. Biosensors and Bioelectronics 151, 111960. Doi: 10.1016/j.bios.2019.111960.
- ; Huang, Chiung-Yin#; Chou, Ya-Wen; Lin, Chia-Jung; Zhou, Zi-Lin; Shiue, Yow-Ling; Wei, Kuo-Chen*; Yang, Hung-Wei* (2019) Bioengineering fluorescent virus-like particle/RNAi nanocomplexes act synergistically with temozolomide to eradicate brain tumors. Nanoscale, 11, 8102-8109. DOI: 10.1039/C9NR01247H.
- ; Chen, Pin-Yuan; Wei, Kuo-Chen; Huang, Chiun-Wei; Shiue, Yow-Ling; Huang, Chiung-Yin; Yang, Hung-Wei (2019) Convection-enhanced delivery of a virus-like nanotherapeutic agent with dual-modal imaging for besiegement and eradication of brain tumors. Theranostics 9, 1752-1763. DOI: 10.7150/thno.30977 [Inside Front Cover].
