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張傳馨 助理研究員

張傳馨 ( Chuan-Hsin Chang)

職稱:助理研究員

學歷:美國科羅拉多大學醫學分校藥理學系毒理學組

分機號碼:5225

電子郵件帳號:chuanhsin@mail.cgust.edu.tw

研究專長: 腫瘤免疫學、新藥研發、毒理學、轉譯醫學、精神免疫學、疾病風險評估

研究室:中草藥研究中心動物評估試驗平台

研究方向:

  1. 探討免疫細胞毒殺癌細胞之相關機制
  2. 抗癌及抗發炎藥物開發
  3. 中草藥或天然物的生化及藥理評估分析(包括細胞或動物模式)之相關研究
  4. 細胞治療之建置
  5. 自體免疫精神疾病之風險因子及機制
  6. 疾病風險因子分析

論文著作:

  1. Chang, C.H.; Chang, Y.C., Yang. L., Tzang, R.F.*, The Comparative Efficacy for Children and Young Adults with Internet Addiction/Internet Gaming Disorder: An Updated Meta-Analysis. Int J Environ Res Publ Health, 2022. 24;19(5):2612.
  2. Tzang, R. F.*; Chang, Y. C.; Chang, C. H., Structural Equation Modeling (SEM): Childhood Aggression and Irritable ADHD Associated with Parental Psychiatric Symptoms. Int J Environ Res Public Health 2021, 18 (19).
  3. Chang, C. H.; Chang, Y. C.; Cheng, H.; Tzang, R. F.*, Treatment Efficacy of Internet Gaming Disorder With Attention Deficit Hyperactivity Disorder and Emotional Dysregulaton. Int J Neuropsychopharmacol 2020, 23 (6), 349-355.
  4. Tzang, R. F.; Chang, C. H.; Chang, Y. C.; Lane, H. Y.*, Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy. Front Psychiatry 2019, 10, 440.
  5. Tzang, R. F.; Chang, C. H.; Chang, Y. C.; Hsu, K.; Chen, C. C.*, Immune modulating therapy: An effective add-on intervention for psychosis of anti-N-methyl-d-aspartate receptor encephalitis in Taiwan. Psychiatry Clin Neurosci 2018, 72 (8), 624-625.
  6. Shiozawa, M.; Chang, C. H.; Huang, Y. C.; Chen, Y. C.; Chi, M. S.; Hao, H. C.; Chang, Y. C.; Takeda, S.; Chi, K. H.; Wang, Y. S.*, Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells. BMC Immunol 2018, 19 (1), 27.
  7. Tzang, R. F.; Chang, C. H.; Chang, Y. C.*, Adolescent's psychotic-like symptoms associated with Internet addiction. Psychiatry Clin Neurosci 2015, 69 (6), 384.
  8. Chang, C. H.; Chang, Y. C.; Tzang, R. F.*, Childhood psychosis after H1N1 influenza. J Neuropsychiatry Clin Neurosci 2015, 27 (1), e87-9.
  9. Chang, C. H.; Drechsel, D. A.; Kitson, R. R.; Siegel, D.; You, Q.; Backos, D. S.; Ju, C.; Moody, C. J.; Ross, D.*, 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol 2014, 85 (6), 849-57.
  10. Kitson, R. R.; Chang, C. H.; Xiong, R.; Williams, H. E.; Davis, A. L.; Lewis, W.; Dehn, D. L.; Siegel, D.; Roe, S. M.; Prodromou, C.; Ross, D.; Moody, C. J.*, Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem 2013, 5 (4), 307-14.
  11. Chang, K. C.; Lo, C. W.; Fan, T. C.; Chang, M. D.; Shu, C. W.; Chang, C. H.; Chung, C. T.; Fang, S. L.; Chao, C. C.; Tsai, J. J.; Lai, Y. K.*, TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells. BMC Cell Biol 2010, 11, 6.
  12. Chuang, C. Y.*; Chang, C. H.; Huang, Y. L., Thioredoxin mediates remodeling factors of human bronchial epithelial cells upon interaction with house dust mite-stimulated eosinophils. Inhal Toxicol 2009, 21 (2), 153-67.

會議論文:

  1. Chuan-Hsin Chang, David Ross, David Siegel, Christopher J Moody, Russell Kitson; Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity. Cancer Res 1 August 2015; 75 (15_Supplement): 1732.
  2. Chuan-Hsin Chang, Derek A. Drechsel, Russell R.A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody, David Ross; Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity. Cancer Res 1 October 2014; 74 (19_Supplement): 1788.
  3. Chuan-Hsin Chang, Russell Kitson, David Siegel, Christopher J. Moody, David Ross; Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs. Cancer Res 15 April 2012; 72 (8_Supplement): 2769.
  4. Chuan-Hsin Chang, Russell Kitson, Philip Reigan, David Siegel, Christopher J. Moody, David Ross; Abstract B102: 19-Substituted benzoquinone ansamycins: Decreasing the toxicity of the benzoquinone ansamycin class of Hsp90 inhibitors. Mol Cancer Ther 12 November 2011; 10 (11_Supplement): B102.