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吳依璇 博士後研究員

基本資料 / Profiles

職稱  / Job Title

藥物研發中心 博士後研究員
Postdoc Fellow, Center for Drug Research and Development

主要學歷 / Education

長庚大學 生物醫學研究所 博士
Ph.D.,Graduate Institute of Biomedical Science, Chang Gung University

聯絡資訊 / Contact

電子信箱 / Email: yhwu03@mail.cgust.edu.tw

分機號碼 / Extension Number: 5230

Open Researcher and Contributor ID (ORCID)

0000-0003-0178-2713

經歷 / Experience
  • 長庚科技大學 藥物研發中心 博士後研究員
  • 長庚大學 醫學暨生物檢驗學系 博士後研究員
研究專長 / Research specialization

人體免疫學、病毒感染學、胚胎發育學、表觀遺傳學
Human immunology, Human infectious disease, Embryogenesis,
Epigenetics

 
研究室及位置 / Lab & Location

F棟4樓 中樞神經系統炎症實驗室
Central Nervous System Inflammation Lab, Building F, 4th Floor

吳依璇博士後研究員照片

吳依璇 博士後研究員
Yi-Hsuan Wu, Postdoc Fellow

研究方向 / Research Focus
  1. 表觀遺傳學在細胞氧化反應與疾病影響的分子機轉
  2. 表觀遺傳學對脂質代謝的探討
論文著作(近五年內著作目錄) / Publications(Selected Papers from the Last Five Years)
  1. Hsieh HL, Yu MC, Chang YC, Wu YH, Huang KH, Tsai MM. (2024) Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9. Curr Issues Mol Biol. Jul 9;46(7):7303-7323. doi: 10.3390/cimb46070433.
  2. Lee TH, Chen JL, Tsai MM, Wu YH, Tseng HC, Cheng LC, Shanmugam V, Hsieh HL. (2023) Protective Effects of Sophoraflavanone G by Inhibiting TNF-α-Induced MMP-9-Mediated Events in Brain Microvascular Endothelial Cells.Int J Mol Sci. Dec 24;25(1):283. doi: 10.3390/ijms25010283.
  3. Wu YH, Hsieh HL. Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer's Disease. Antioxidants (Basel). 2023 Sep 30;12(10):1816. doi: 10.3390/antiox12101816.
  4. Wu YH, Hsieh HL. Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders. Antioxidants (Basel). 2022 May 8;11(5):923. doi: 10.3390/antiox11050923.
  5. Lee YT, Chen YL, Wu YH, Chen IS, Chang HS, Wang YH, Chang SH, Wu YH, Kao TI, Yu HP, Hwang TL. Meso-Dihydroguaiaretic Acid Ameliorates Acute Respiratory Distress Syndrome through Inhibiting Neutrophilic Inflammation and Scavenging Free Radical. Antioxidants (Basel). 2022 Jan 6;11(1):123. doi: 10.3390/antiox11010123.
  6. Wu YH, Kuo CF, Hsieh AH, Hsieh HL, Chan YF, Hwang TL. Upregulation of miR-210-5p impairs dead cell clearance by macrophages through the inhibition of Sp1-and HSCARG-dependent NADPH oxidase
    pathway. Free Radic Biol Med. 2021 Aug 20;172:441-450. doi: 10.1016/j.freeradbiomed.2021.06.029.
  7. Lai KH, Chen PJ, Chen CC, Yang SH, El-Shazly M, Chang YC, Wu YH, Wu YH, Wang YH, Hsieh HL, Hwang TL.Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK
    and calcium. J Ethnopharmacol. 2021 Jan 10;264:113224. doi: 10.1016/j.jep.2020.113224.
  8. Chang YC, Lai KH, Kumar S, Chen PJ, Wu YH, Lai CL, Hsieh HL, Sung PJ, Hwang TL. 1 H NMR-Based Isolation of Anti-Inflammatory 9,11-Secosteroids from the Octocoral Sinularia leptoclados. Mar Drugs. 2020 May 21;18(5):271. doi: 10.3390/md18050271.
  9. Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun- Yee Chiu D. Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox
    signaling. Redox Biol. 2020 Jan;28:101363. doi: 10.1016/j.redox.2019.101363.