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張祐嘉 助理研究員

張祐嘉 (Yu-Chia Chang)

職稱：助理研究員

學歷：國立中山大學海洋生物科技博士學位學程

分機號碼：5221 

電子郵件帳號：ycchang03@mail.cgust.edu.tw

研究專長： 天然物化學、分析化學、中草藥/海洋新藥開發、化粧品有效原料開發、機能性食品原料開發

研究室：中草藥研究中心中草藥製備暨化學分析平台

研究方向：
  1. 自藥用植物與海洋無脊椎生物中尋找具活性的新穎天然物
  2. 化妝品原料與機能性食品原料研發
  1. Discovery and structural elucidation of novel natural products with biological activities from medicinal plants and marine invertebrates.
  2. Cosmetic API and functional Food R&D.

論文著作：
  1. Phan, G.-H.; Tsai, Y.-C.; Liu, Y.-H.; Fang, L.-S.; Wen, Z.-H.; Hwang, T.-L.; Chang, Y.-C.*; Sung, P.-J.* (2021) Sterol Constituents from a Cultured Octocoral Sinularia sandensis (Verseveldt 1977) J.Mol.Struc., 131175.
  2. Kumar, S.; Wang, Y.-H.; Chen, P.-J.; Chang, Y.-C.; Kashyap, H. K.; Shen, Y.-C.; Yu, H.-P.; Hwang, T.-L. (2021) Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents. Bioorg. Chem., 111, 104846.
  3. Lai, K.-H.; Chen, C.-C.; El-Shazly, M.; Wu, Y.-H.; Chen, P.-J.; Wu, Y.-H.; Hsieh, H.-L.; Wang, Y.-H.; Chang, Y.-C.; Hwang, T.-L. (2021) Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. J. Ethnopharmacol. 264, 113224.
  4. Chang, Y.-C.†; Chiang, C.-C.†; Chang, Y.-S.; Chen, J.-J.; Wang, W.-H.; Fang, L.-S.; Chung, H.-M.; Hwang, T.-L.; Sung, P.-J. (2020) Novel Caryophyllane‐Related Sesquiterpenoids with Anti‐Inflammatory Activity from Rumphella antipathes (Linnaeus, 1758) Mar. Drugs, 18, 554.
  5. Kumar, S.; Chang, Y.-C.; Lai, K.-H.; Hwang, T.-L. (2020) Resveratrol, a molecule with anti-inflammatory and anti-cancer activities: journey from natural product to chemical synthesis. Curr. Med. Chem. 27, 1–14
  6. Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Zheng, L.-G.; Huang, P.-C.; Huynh, T.-H.; Peng, B.-R.; Chen, Y.-Y.; Wu, Y.-J.; Fang, L.-S.; Su, J.-H.; Hsu, C.-M.; Sung, P.-J. (2020) Natural Products from Octocorals of the Genus Dendronephthya (Family Nephtheidae) Molecules, 25, 5957.
  7. Chen, P.-J.; Kuo, L.-M.; Wu, Y.-H.; Chang, Y.-C.; Lai, K.-H.; Hwang, T.-L. (2020) BAY 41-2272 attenuates CTGF expression via Akt-dependent but sGC/cGMP-independent pathway in TGFβ1-activated hepatic stellate cells. Biomedicines, 8(9), 330.
  8. Peng, B.-R.; Lai, K.-H.; Chang, Y.-C.; Chen, Y.-Y.; Su, J.-H.; Huang, Y. M.; Chen, P.-J.; Yu, Steve S.-F.; Duh, C.-Y.; Sung, P.-J. (2020) Sponge-derived 24-Homoscalaranes as Potent Anti-inflammatory Agents. Mar. Drugs, 18(9), 434.
  9. Chang, Y.-C.; Lai, K.-H.; Kumar, S.; Chen, P.-J.; Wu, Y.-H.; Lai, C.-L.; Hsieh, H.-L.; Sung, P.-J.; Hwang, T.-L. (2020) 1H NMR-based isolation of anti-inflammatory 9,11-secosteroids from the octocoral Sinularia leptoclados. Mar. Drugs, 18(5), 271.
  10. Hu, C.-C.; Lin, N.-C.; Peng, B.-R.; Chen, Y.-Y.; Wen, Z.-H.; Chang, Y.-C.; Lee, G.-H.; Wu, Y.-C.; Sung, P.-J. (2020) New trihydroxybriarane diterpenoids from an octocoral Briareum sp. Phytochem. Lett. 35, 23–27.
  11. Huang, P.-C.; Lin, W.-S.; Peng, B.-R.; Chang, Y.-C.; Fang, L.-S.; Li, G.-Q.; Hwang, T.-L.; Wen, Z.-H.; Sung, P.-J. (2019) New Furanocembranoids from Briareum violaceum. Mar. Drugs, 17, 214.
  12. Xua, J.-H.; Chang, Y.-C.; Li, G.-Q.; Wen, Z.-H.; Wu, Y.-C.; Sung, P.-J. (2018) Briaviolides O and P, new briaranes from a cultured octocoral Briareum violaceum. Phytochem. Lett. 27, 129–133.
  13. Zheng, L.-G.; Chang, Y.-C.; Chen, J.-J.; Wen, Z.-H.; Hwang, T.-L.; Sung, P.-J. (2018) (+)-12-epi-Fragilide G, a New Chlorinated Briarane from the Sea Whip Gorgonian Coral Junceella fragilis. Heterocycles, 96(9), 1601–1609.
  14. Zheng, L.-G.; Chang, Y.-C.; Hu, C.-C.;Wen, Z.-H.; Wu, Y.-C.; Sung, P.J. (2018) Fragilides K and L, New Briaranes from the Gorgonian Coral Junceella fragilis. Molecules, 23(7), 1510.
  15. Ning, C.; David Wang, H.-M.; Gao, R.; Chang, Y.-C.; Hu, F.; Meng, X.; Huang, S.-Y. (2018) Marine-derived protein kinase inhibitors for neuroinflammatory diseases. Biomed. Eng. Online 17 (1), 46.
  16. Xu, J.-H.; Lai, K.-H.; Su, Y.-D.; Chang, Y.-C.; Peng, B.-R.; Backlund, A.; Wen, Z.-.; Sung, P.-J. (2018) Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum. Mar. Drugs, 16(3), 75.
  17. Kuo, L.-M.; Chen P.-J.; Sung, P.J.; Chang, Y.-C.; Ho, C.-T.; Wu, Y.-H.; Hwang, T.-L. (2018) The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling. Mar. Drugs, 16(1), 19.
  18. Chang, Y.-C.; Sheu, J.-H.; Wu, Y.-C.; Sung, P.-J. (2017). Terpenoids from Octocorals of the Genus Pachyclavularia. Mar. Drugs, 15(12), 382.
  19. Chang, Y.-C. †; Hwang, T.-L. †; Chao, C.-H.; Sung, P.-J. (2017). New Marine Sterols from a Gorgonian Pinnigorgia sp. Molecules, 22(3), 393.
  20. Chang, Y.-C.; Hwang, T.-L.; Kuo, L.-M.; Sung, P.-J. (2017). Pinnisterols D–J, New 11-Acetoxy-9, 11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp.(Gorgoniidae). Mar. Drugs, 15(1), 11.
  21. Chen, W.-F. †; Chang, Y.-C. †; Chiu, Y.-W.; Fang, L.-S.; Chen, Y.-H.; Su, Y.-D.; Peng, B.-R.; Lu, M.-C.; Chen, J.-J.; Wen, Z.-H.; Wu, Y.-C.; Sung, P.-J. (2016). Oxytoxin-2, An Algal-Derived Molecule from a Cultured Mollusc Volvatella vigourouxi. Nat. Prod. Commun., 12, 1783–1784.
  22. Whuang, T.-Y.; Tsai, W.-C.; Chen, N.-F.; Chen, Z.-C.; Tsui, K.-H.; Wen, Z.-H.; Su, Y.-D.; Chang, Y.-C.; Chen, Y.-H.; Lu, M.-C.; Fang, L.-S.; Chen, J.-J.; Wu, T.-Y.; Wu, Y.-C.; Sung, P.-J. (2016). Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris. Bioorg. Med. Chem. Lett., 26, 4966–4969.
  23. Chen, Y.-H.; Lu, M.-C.; Chung, H.-M.; Weng, C.-F.; Su, J.-H.; Yang, Y.-T.; Su, Y.-D.; Chang, Y.-C.; Kuo, J.; Wu, Y.-C.; Sung, P.-J. (2016). Bafilomycin M, a new cytotoxic bafilomycin produced by a Streptomyces sp. isolated from a marine sponge Theonella sp. Tetrahedron Lett., 57, 4863–4865.
  24. Peng, K.-Y.; Chen, N.-F.; Chen, Z.-C.; Tsui, K.-H.; Wen, Z.-H.; Su, Y.-D.; Chang, Y.-C.; Chen, Y.-H.; Lu, M.-C.; Fang, L.-S.; Chen, J.-J.; Wu, T.-Y.; Wu, Y.-C.; Sung, P.-J. (2016). Cladieunicellins R and S, new eunicellins from the Formosan octocoral Cladiella tuberculosa. Tetrahedron Lett., 57, 4239–4242.
  25. Chang, Y.-C.; Chen, N.-F.; Hwang, T.-L.; Tseng, C.-C.; Wu, T.-Y.; Peng, B.-R.; Wen, Z.-H.; Fang, L.-S.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. (2016). New marine sterols from an algal-bearing gorgonian coral Pinnigorgia sp. Steroids 115, 123–119.
  26. Chang, H.-H.†; Chang, Y.-C.†; Chen, W.-F.; Hwang, T.-L.; Fang, L.-S.; Wen, Z.-H.; Chen,Y.-H.; Wu, Y.-C.; Sung, P.-J. (2016). Pubinernoid A and Apo-9'-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp. Nat Prod Commun. 11, 707–708.
  27. Chang, Y.-C. ; Hwang, T.-L.; Sheu, J.-H.; Wu, Y.-C.; Sung, P.-J. (2016). New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. Mar. Drugs 14, 218.
  28. Chang, Y.-C. ; Kuo, L.-M. ; Hwang, T.-L.; Yeh, Jessica; Wen, Z.-H.; Fang, L.-S.; Wu, Y.-C.; Lin, C.-S.; Sheu, J.-H.; Sung, P.-J. (2016). Pinnisterols A−C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. Mar. Drugs 14(1), 12.
  29. Chang, Y.-C. †; Kuo, L.-M. †; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Lin, C.-S.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. (2016). Pinnigorgiols A−C, 9,11-Secosterols with a Rare Ring Arrangement from a Gorgonian Coral Pinnigorgia sp. Tetrahedron 72, 999–1004.
  30. Su, Y.-D.; Wen, Z.-H.; Wu, Y.-C.; Fang, L.-S.; Chen, Y.-H.; Chang, Y.-C.; Sheu, J.-H.; Sung, P.-J.  (2016). Briarenolides M−T, New Briarane Diterpenoids from a Formosan Octocoral Briareum sp. Tetrahedron 72, 944–951.

會議論文：
  1. Yu-Chia Chang, Hsi-Lung Hsieh, Ching-Long Lai*, Tsong-Long Hwang*“Bioactivity-guided Isolation of Anti-inflammatory 9,11-Secosteroids from the Soft Coral Sinularia leptoclados”第三十四屆天然藥物研討會，2019，桃園，長庚科技大學，Taiwan。
  2. Yu-Chia Chang, Chan-Shing Lin, Ping-Jyun Sung*“Chemical Constituents and Their Bioactivities from a Formosan Gorgonian Coral Pinnigorgia sp.”第三十一屆天然藥物研討會，2016，高雄，國立中山大學，Taiwan。
  3. Yu-Chia Chang, Chan-Shing Lin, Jyh-Horng Sheu, Ping-Jyun Sung* “New marine sterols from a Formosan gorgonian coral Pinnigorgia sp.” International Symposium on Natural Products for the Future，2016， Tokushima，Japan。