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中心成員

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中心主任

基本資料 / Profiles

職稱  / Job Title

民生學院 院長
Dean, College of Human Ecology

藥物研發中心 主任
Director, Center for Drug Research and Development

健康產業科技研究所 專任教授
Professor, Graduate Institute of Health Industry Technology

主要學歷 / Education

國防醫學院 生命科學研究所博士
PhD, Institute of Life Sciences, National Defense Medical Center

聯絡資訊 / Contact

電子信箱 / Email: hlhsieh@mail.cgust.edu.tw

分機號碼 / Extension Number: 5715

Open Researcher and Contributor ID (ORCID)

0000-0001-8302-2472

經歷 / Experience
  • 長庚科技大學 民生學院 院長
  • 長庚科技大學 藥物研發中心 主任
  • 長庚科技大學 中草藥研究中心 主任
  • 長庚科技大學 護理系基礎醫學組 組長
  • 多項科技部及產學合作計畫主持人
研究專長 / Research specialization

細胞訊息傳遞、發炎藥理學、神經免疫調控
Cell signaling, Inflammatory pharmacology, Neuro-immune regulation

研究室/實驗室成員 / Lab Members
  • 博士後研究員 (Postdoctoral Research Fellow)：2 人
  • 研究助理 (Research Assistants)：3 人
  • 研究生 (Graduate Students)：4 人
  • 大學部專題生 (Undergraduate Students)：3 人
研究室及位置 / Lab & Location

F棟4樓 中樞神經系統炎症實驗室
Central Nervous System Inflammation Lab, Building F, 4th Floor

中心主任照片

謝喜龍 教授
Prof. Hsi-Long Hsieh
民生學院院長兼中心主任

研究方向 / Research Focus

1. 神經發炎與中樞神經系統疾病機轉探討
2. 神經與中樞神經系統老化機轉探討
3. 天然物/中草藥與小分子藥物於細胞效用評估

論文著作(近五年內著作目錄) / Publications(Selected Papers from the Last Five Years)
  1. Hsi-Lung Hsieh, Ming-Chin Yu, Yu-Chia Chang, Yi-Hsuan Wu, Kuo-Hsiung Huang, Ming-Ming Tsai. (2024) Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9. Current Issues in Molecular Biology (Curr Issues Mol Biol) 2024 Jul 9;46(7):7303-7323. doi: 10.3390/cimb46070433.
  2. Tsong-Hai Lee, Jiun-Liang Chen, Chuan-Hsin Chang, Ming-Ming Tsai, Hui-Ching Tseng, Yu-Chia Chang, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh*. (2024) A Brain-Protective Sterol from Soft Coral Inhibits Lipopolysaccharide-Induced Matrix Metalloproteinase-9-Mediated Astrocytic Migration. Biomedicines 12(1): 226. doi: 10.3390/biomedicines12010226.
  3. Tsong-Hai Lee, Jiun-Liang Chen, Ming-Ming Tsai, Yi-Hsuan Wu, Hui-Ching Tseng, Li-Ching Cheng, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh*. (2023) Protective Effects of Sophoraflavanone G by Inhibiting TNF-α-Induced MMP-9-Mediated Events in Brain Microvascular Endothelial Cells. International Journal of Molecular Sciences (Int. J. Mol. Sci.) 25(1): 283. doi: 10.3390/ijms25010283.
  4. Yi-Hsuan Wu, Hsi-Lung Hsieh*. (2023) Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer's Disease. Antioxidants (Basel) 12(10):1816. doi: 10.3390/antiox12101816.
  5. Chun-Han Su, Yu-Chieh Cheng, Yu-Chia Chang, Ting-Hsuan Kung, Yu-Li Chen, Kuei-Hung Lai, Hsi-Lung Hsieh, Chun-Yu Chen*, Tsong-Long Hwang*, Yu-Liang Yang*. (2022/7) Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit. Molecules 27(14):4462. doi: 10.3390/molecules27144462.
  6. Hsi-Lung Hsieh+, Shih-Hai Liu+, Ya-Ling Chen, Chien-Yi Huang, Shu-Ju Wu*. (2022) Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells. Archives of Physiology and Biochemistry (Arch. Physiol. Biochem.) 128(3):757-766. doi: 10.1080/13813455.2020.1727525.
  7. Ming-Ming Tsai†, Jiun-Liang Chen†, Tsong-Hai Lee†, Hsiuming Liu, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh*. (2022) Brain Protective Effect of Resveratrol via Ameliorating Interleukin-1-Induced MMP-9-Mediated Disruption of ZO-1 Arranged Integrity. Biomedicines 10(6):1270. doi: 10.3390/biomedicines10061270.
  8. Yi-Hsuan Wu, Hsi-Lung Hsieh*. (2022) Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders. Antioxidants (Basel) 11(5):923. doi: 10.3390/antiox11050923.
  9. Hsi-Lung Hsieh+, Ming-Chin Yu+, Li-Ching Cheng+, Mei-Yi Chu, Tzu-Hao Huang, Ta-Sen Yeh, Ming-Ming Tsai*.  (2022) Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells. World Journal of Gastroenterology 28(11):1139-1158. doi: 10.3748/wjg.v28.i11.1139.
  10. Hsi-Lung Hsieh+, Ming-Chin Yu+, Li-Ching Cheng+, Ta-Sen Yeh, Ming-Ming Tsai*.  (2022) Molecular mechanism of therapeutic approaches for human gastric cancer stem cells. World Journal of Stem Cells 14(1):76-91. doi: 10.4252/wjsc.v14.i1.76.
  11. Mallikarjun Gundappa, Vijaya Anand Arumugam, Hsi-Lung Hsieh, Balamuralikrishnan Balasubramanian, Velayuthaprabhu Shanmugam*.  (2022) Expression of tissue factor and TF-mediated integrin regulation in HTR-8/SVneo trophoblast cells. Journal of Reproductive Immunology 150:103473.doi: 10.1016/j.jri.2022.103473.
  12. Hsi-Lung Hsieh+, Ching-Chung Liang+, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung+, Yu-Shien Ko, Tsong-Hai Lee*. (2021) Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat. Stem Cell Research & Therapy 12(1):549. doi: 10.1186/s13287-021-02615-z.
  13. Te-Chien Ku, Pin-Han Wang, Jhen-Ling Huang, Hsing-Yu Chen, Ji-Tseng Fang, Hsi-Lung Hsieh*, Jiun-Liang Chen*. (2021) The survival outcome of nasopharyngeal cancer patients with traditional Chinese medicine external use: A hospital-based study. Journal of Ethnopharmacology 279:114380-114389. doi: 10.1016/j.jep.2021.114380.
  14. Tong-Hong Wang+, Chin-Chuan Chen+, Yann-Lii Leu, Yun-Shien Lee, Jang-Hau Lian, Hsi-Lung Hsieh*, Chi-Yuan Chen*. (2021) Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma.  Journal of the Formosan Medical Association, 120(9):1695-1705. doi: 10.1016/j.jfma.2020.12.009.
  15. Tsong-Hai Lee†, Pei-Shan Liu†, Su-Jane Wang, Ming-Ming Tsai, Velayuthaprabhu Shanmugam and Hsi-Lung Hsieh*. (2021) Bradykinin, as a Reprogramming Factor, Induces Transdifferentiation of Brain Astrocytes into Neuron-Like Cells. Biomedicines 9(8): 923. doi: 10.3390/biomedicines9080923.
  16. Yi-Hsuan Wu, Chang-Fu Kuo, Ao-Ho Hsieh, Hsi-Lung Hsieh, Yen-Fan Chan, Tsong-Long Hwang*. (2021) Upregulation of miR-210-5p impairs dead cell clearance by macrophages through the inhibition of Sp1-and HSCARG-dependent NADPH oxidase pathway. Free Radical Biology and Medicine 172:441-450.  doi: 10.1016/j.freeradbiomed.2021.06.029.
  17. Kuei-Hung Lai+, Po-Jen Chen+, Chih-Chuan Chen, Sien-Hung Yang, Mohamed El-Shazly, Yu-Chia Chang, Yi-Hsuan Wu, Yi-Hsiu Wu, Yi-Hsuan Wang, Hsi-Lung Hsieh*, Tsong-Long Hwang*. (2021) Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. Journal of Ethnopharmacology 264:113224-113233.   doi: 10.1016/j.jep.2020.113224.
  18. Tsong-Hai Lee†, Pei-Shan Liu†, Ming-Ming Tsai†, Jiun-Liang Chen, Su-Jane Wang, Hsi-Lung Hsieh*. (2020) The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling. Cell Communication and Signaling 18(1):185-197. doi: 10.1186/s12964-020-00680-0.
  19. Tsong-Hai Lee+, Jiun-Liang Chen+, Pei-Shan Liu+, Ming-Ming Tsai, Su-Jane Wang, Hsi-Lung Hsieh*. (2020) Rottlerin, a natural polyphenol compound, inhibits up-regulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal. Journal of Neuroinflammation 17(1):177-189. doi: 10.1186/s12974-020-01859-5.
  20. Yu-Chia Chang, Kuei-Hung Lai, Sunil Kumar, Po-Jen Chen, Yi-Hsuan Wu, Ching-Long Lai, Hsi-Lung Hsieh*, Ping-Jyun Sung*, Tsong-Long Hwang*. (2020) 1H NMR-Based Isolation of Anti-Inflammatory 9,11-Secosteroids from the Octocoral Sinularia leptoclados. Marine Drugs  18(5): 271-280. doi: 10.3390/md18050271.
個人學術研究 / Academic Research

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