中心主任
基本資料 / Profiles
黃聰龍 特聘教授
Prof. Tsong Long Hwang
長庚科技大學副校長 兼 藥物研發中心主任
現職 / Current Position
長庚科技大學 副校長Vice President, Chang Gung University of Science and Technology
藥物研發中心 主任Director, Center for Drug Research and Development
健康產業科技研究所 特聘教授Distinguished Professor, Graduate Institute of Health Industry Technology
主要學歷 / Education
臺灣大學藥理學研究所博士PhD, Institute of Pharmacology, National Taiwan University
研究專長 / Research Specialization
發炎免疫藥理學、天然物藥學、分子訊號傳遞、藥妝和保健產品開發Inflammatory Pharmacology, Natural Medicine, Molecular Signaling, Drug Discovery, Cosmetic and Healthcare Product Development
實驗室成員與位置 / Lab Members & Location
成員配置：
- 博士後研究員：3 人
- 研究助理： 8人
- 研究生： 12人(博士班4人、研究生8人)
- 大學部專題生： 8人
實驗室位置：
E棟6樓 發炎藥理學研究室Cellular Pharmacology Laboratory
最近研究主題 / Recent Research Topics
一、研究計畫 (Research Projects)
- 開發臺灣蘭科植物作為改善發炎代謝失調的功能性食品 (Development of Taiwanese Orchidaceae as Functional Foods to Improve Inflammatory Metabolic Disorders)
- 研究和開發cAMP 提升劑治療嗜中性白血球發炎疾病 (Research and Development of cAMP Enhancers for Treating Neutrophilic Inflammatory Diseases)
- (長長科)整合型基於傳統中藥配方尋找標靶嗜中性白血球發炎的關鍵藥材:治療急性呼吸窘迫症及腫瘤之總計畫 ((CGUST) Integrated Project on Identifying Key Medicinal Materials Targeting Neutrophilic Inflammation Based on Traditional Chinese Medicine Formulas: Overall Project for Treating Acute Respiratory Distress Syndrome and Tumors)
- 探討錫蘭七指蕨之Ugonins化合物調控人類嗜中性白血球發炎反應的分子機制 (Investigating the Molecular Mechanism of Ugonins Compounds from Angiopteris evecta in Regulating Human Neutrophilic Inflammatory Responses)
- 整合型系統性探討金銀花(Lonicera japonica)於炎症相關病變之治療活性與解開其作用機轉之謎之總計畫 (Integrated Systematic Investigation of the Therapeutic Activity of Honeysuckle (Lonicera japonica) in Inflammation-Related Lesions and Elucidating its Mechanism of Action: Overall Project)
二、產學合作案 (Industry-Academia Collaboration Projects)
- 外泌體生髮功效測試 (Exosome Hair Growth Efficacy Test)
- FPR1拮抗劑藥效測試 (FPR1 Antagonist Efficacy Test)
- GPCR體外活性鑑定與嚴重氣喘動物藥效測試 (GPCR In Vitro Activity Identification and Severe Asthma Animal Efficacy Test)
- ARDS和氣喘動物模型建立 (ARDS and Asthma Animal Model Establishment)
- 外泌體對生髮效果、發炎反應(含分子機制尋找)及傷口癒合之功效 (Efficacy of Exosomes on Hair Growth, Inflammatory Response (Including Molecular Mechanism Search), and Wound Healing)
- 組織培養白芨CMC指標成分檢測 (Tissue Culture Bletilla striata CMC Marker Component Detection)
- 植物新藥開發：臨床前治療效果試驗 (Phytopharmaceutical Development: Pre-clinical Therapeutic Efficacy Trials)
- 植物性保養品的原料製程暨功能開發 (Raw Material Process and Functional Development of Plant-based Skincare Products)
- 3D毛囊組織生髮技術開發暨生髮原料功能篩選 (3D Hair Follicle Tissue Hair Growth Technology Development and Hair Growth Raw Material Function Screening)
論文著作 (近五年內著作目錄) / Publications
- Chen SH, Chen CH, Lin HC, Yeh SA, Hwang TL*, Chen PJ*. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis. J Adv Res. 2025 Jun:72:485-500.
- Chiang CC, Cheng, WJ, Dela Cruz JRMS, Raviraj T, Wu NL*, Korinek M*, Hwang TL*. Neutrophils in Atopic Dermatitis. Clin Rev Allergy Immunol. 2024 Dec;67(1-3):21-39. Epub 2024 Sep 18.
- Chen PJ, Chen SH, Chen YL, Wang YH, Lin CY, Chen CH, Tsai YF, Hwang TL*. Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. J Adv Res. 2024 Aug:62:229-243. Epub 2024 Mar 27.
- Chen PJ, Tseng HH, Wang YH, Fang SY, Chen SH, Chen CH, Tsai SC, Chang YC, Tsai YF, Hwang TL*. Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis. Br J Pharmacol. 2023 Aug;180(16):2172-2188. Epub 2023 Apr 19.
- Yang SC, Wang YH, Ho CM, Tsai YF, Sung PJ, Lin TE, Hwang TL*. Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome. Br J Pharmacol. 2023 Aug;180(16):2120-2139. Epub 2023 Apr 10.