廖柏翔 博士

基本資料 / Profiles

藥物研發中心廖柏翔助理研究員個人半身正裝照
廖柏翔 助理研究員
Po-Hsiang Liao, Assistant Research Fellow
藥物研發中心助理研究員
現職 / Job Title
 

藥物研發中心 助理研究員Assistant Research Fellow, CDRD

聯絡資訊 / Contact
 

信箱：phliao@mail.cgust.edu.tw

分機：5266

ORCID：0000-0002-4266-5428 🔗

主要學歷 / Education
 

中國醫藥大學 基礎醫學研究所 博士Ph.D., Institute of Basic Medical Sciences, China Medical University

經歷 / Experience
 
  • 花蓮慈濟醫學中心 外泌體暨粒線體疾病研究中心 助理研究員
  • 衛生福利部雙和醫院 一般外科 醫學研究員
  • 中國醫藥大學附設醫院 外泌體暨粒線體疾病醫學研究中心 助理研究員
研究專長 / Specialization
 

分子醫學、癌症抗藥性、代謝與老化相關疾病Molecular Medicine, Cancer Drug Resistance, Metabolism and Aging-related Diseases

實驗室成員 / Lab Members
 

研究助理：2 人

專題生：2 人 

實驗室位置 / Lab Location
 

位置：E棟4樓 分子醫學研究室Laboratory of Molecular Medicine, Building E, 4F

研究方向 / Research Focus
 
  1. 癌症抗藥性分子機轉探討：深入研究腫瘤細胞面對藥物時的逃逸與耐藥機制。(Molecular mechanisms of cancer drug resistance)
  2. 代謝性與老化相關疾病機轉探討：著重於老齡化社會下，慢性代謝疾病的細胞分子病理基礎。(Mechanisms of metabolic and aging-related diseases)
  3. 中草藥/天然物與單一成分應用評估：自天然植物中篩選活性小分子，進行功能性與治療潛力驗證。(Evaluation of herbal medicines, natural compounds, and their active constituents)
  4. 健康食品開發與評估：連結基礎實驗數據，研發兼具科學實證與保健功效的生技食品。(Development and evaluation of health foods)
論文著作 (近五年內著作目錄) / Publications (Selected Papers)
 
  1. Hsu TW, Wang WY, Chen A, Chiu CF, Liao PH, Chen HA, Su CM, Tsai KY, Wang TH and Su YH. (2024, Aug). Nrf2-mediated ADSL promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma cells through ferroptosis escape. Journal of Cellular Physiology.
  2. Ho TJ, Tamilselvi Shanmugam, Liao PH, Shibu MA, Chen ST, Lin KH, Lu SY, Kuo CH, Kuo WW and Huang CY. (2024, May). Renal protective effects of Alpinate Oxyphyllae Fructus and mesenchymal stem cells co-treatment against D-galactose induced renal deterioration. International Journal of Medical Science, 21(8):1491-1499.
  3. Chiu CH, Lin YJ, Ramesh S, Kuo WW, Chen MC, Kuo CH, Li CC, Wang TF, Lin YM, Liao PH, Huang CY (2023, Aug). Gemcitabine resistance in non-small cell lung cancer is mediated through activation of the PI3K/AKT/NF-κB pathway and suppression of ERK signaling by reactive oxygen species. Journal of Biochemical and Molecular Toxicology, e23497.
  4. Chiu CH, Ramesh S, Liao PH, Kuo WW, Chen MC, Kuo CH, Li CC, Wang TF, Lin YM, Lin YJ and Huang CY (2023, Sep). Phosphorylation of Bcl-2 by JNK confers gemcitabine resistance in lung cancer cells by reducing autophagy-mediated cell death. Environmental Toxicology, 38(9):2121-2131.
  5. Hsu TW, Su YH, Chen HA, Liao PH, Shen SC, Tsai KY, Wang TH, Chen A, Huang CY, Shibu MA, Wang WY, Shen SC (2023, Jul). Galectin-1-mediated MET/AXL signaling enhances sorafenib resistance in hepatocellular carcinoma by escaping ferroptosis. Aging (Albany NY), 15(13):6503-6525.
  6. Su CM, Hsu TW, Chen HA, Wang WY, Huang CY, Huang CC, Yeh MH, Su YH, Huang MT and Liao PH* (2023, Apr). Chaperone-mediated autophagy degrade Dicer to promote breast cancer metastasis. Journal of Cellular Physiology, 238(4):829-841.
  7. Lee TK, Ashok Kumar K, Huang CY, Liao PH, Ho TJ, Kuo WW, Liao SC, Hsieh DJ, Chiu PL, Chang YM, Ju DT (2023, Mar). Garcinol protects SH-SY5Y cells against MPP+-induced cell death by activating DJ-1/SIRT1 and PGC-1α mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy. Environmental Toxicology, 38(4):857-866.
  8. Hsu TW, Chen HA, Liao PH, Su YH, Chiu CF, Huang CY, Lin YJ, Hung CC, Yeh MH, Sung SY, Su CM (2022, Aug). Dicer-mediated miR-200b expression contributes to cell migratory/invasive abilities and cancer stem cells properties of breast cancer cells. Aging (Albany NY), 14(16):6520-6536.
  9. Liu YS, Chang YC, Kuo WW, Chen MC, Wang TF, Chen TS, Lin YM, Li CC, Liao PH* and Huang CY* (2022, Jun). Calreticulin nuclear translocalization alleviates CaM/CaMKII/CREB signaling pathway to enhance chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells. Aging (Albany NY), 14(12):5097-5115.
  10. Su CM, Hsu TW, Sung SY, Huang MT, Chen KC, Huang CY, Chiang CY, Su YH, Chen HA and Liao PH* (2021, Jul). AXL is crucial for E1A-enhanced therapeutic efficiency of EGFR tyrosine kinase inhibitors through NFI in breast cancer. Environmental Toxicology, 36(7):1278-1287.
  11. Chen HA, Li CC, Lin YJ, Wang TF, Chen MC, Su YH, Yeh YL, Padma VV, Liao PH* and Huang CY* (2021, Apr). Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells. Aging (Albany NY), 13(8):12046-12057.
  12. Chang YM, Manoj Kumar M, Lu CY, Te Tsai C, Tsai CC, Liao PH, Lin SL, Chang CC, Mahalakshmi B, Kuo WW, Huang CY. (2020, Sep). Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life Sciences, 257:118019.
  13. Hsieh JY, Marte L, Kuo WW, Ju DT, Chen ST, Kuo CH, Day H, Mahalakshmi B, Liao PH* and Huang CY* (2020, Jul). Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain. International Journal of Medical Sciences, 17(13):1916-1926.
  14. Huang CY, Sivalingam K, Shibu MA, Liao PH, Ho TJ, Kuo WW, Chen RJ, Day H, Viswanadha VP and Ju DT (2020, Jun). Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels. Nutrients, 12(6):1707.
  15. Chang YM, Ashok Kumar K, Ju DT, Ho TJ, Mahalakshmi B, Lin WT, Day CH, Vijaya PV, Liao PH*, Huang CY (2020, May). Dipeptide IF prevents the effects of hypertension-induced Alzheimer's disease on long-term memory in the cortex of spontaneously hypertensive rats. Environmental Toxicology.
個人學術研究 / Academic Research
 

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