張祐嘉 博士

基本資料 / Profiles

藥物研發中心張祐嘉助理研究員個人半身正裝照
張祐嘉 助理研究員
Yu-Chia Chang, Assistant Research Fellow
藥物研發中心助理研究員 兼 化妝品應用系助理教授
現職 / Job Title
 

藥物研發中心 助理研究員Assistant Research Fellow, CDRD

化妝品應用系 兼任助理教授Adjunct Assistant Professor, Dept. of Cosmetic Science

聯絡資訊 / Contact
 

信箱：ycchang03@mail.cgust.edu.tw

分機：5267

ORCID：0000-0002-7849-8254 🔗

主要學歷 / Education
 

國立中山大學 海洋生物科技博士學位學程Ph.D. in Marine Biotechnology, National Sun Yat-Sen University

經歷 / Experience
 
  • 長庚科技大學 藥物研發中心 助理研究員
  • 長庚科技大學 化妝品應用系 兼任助理教授
  • 台塑生醫科技公司 產品研發顧問
  • 工業技術研究院 溫室系統技術中心 研究員
研究專長 / Specialization
 

天然物化學與分析化學、結構鑑定與代謝體學、植物與海洋生物萃取技術、化妝品及保健品原料開發Natural Products Chemistry, Structure Elucidation & Metabolomics, Extraction Techniques, Cosmetic Ingredients R&D

實驗室成員 / Lab Members
 

研究助理：1 人

專題生：1 人 

實驗室位置 / Lab Location
 

位置：E棟4樓 天然物探索核心實驗室Natural Products Discovery Core Lab, Building E, 4F

研究方向 / Research Focus
 
  1. 海洋天然物化學研究：自軟珊瑚與海洋生物分離具抗癌與免疫調控活性之新穎天然物。(Marine Natural Products Chemistry: Isolation of bioactive metabolites from soft corals for anti-cancer/immunomodulatory effects.)
  2. 台灣原生植物及中草藥活性成分研究：開發特有植物與中草藥在抗發炎、抗代謝失調與促進傷口癒合之應用。(Bioactives from Taiwanese Indigenous Plants: Focus on anti-inflammatory, metabolic, and chronic wound-healing applications.)
  3. 新藥與健康素材開發：結合天然物化學與網絡藥理學，建立新藥候選物與功能性食品/化妝品原料研發平台。(Drug and Health Material Development: Integrating natural product chemistry and network pharmacology.)
  4. 產業應用與技術商品化：推動天然物研究成果專利申請、技術移轉與產學合作。(Industrial Application & Technology Commercialization: Patenting and technology transfer.)
論文著作 (近五年內著作目錄) / Publications (Selected Papers)
 
  1. Ahmed, Wadaa A.; Kamal, Amel M.; Abdelhady, Mohamed I.S.; Mohamed, Kuo, S.-L.; Su, C.-H.; Lai, K-H.; Chang, Y.-C.; You, J.-S.; Peng, H.-H.; Chen, C.-H.; Lin, C.-C.; Chen, P.-J.; Hwang, T.-L. (2025) Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice. Biomedical Journal. 48, 100731.
  2. Do H.-N. ; Huang, C.-Y. , Chien, S.-Y.; Zheng, L.-G.; Chen, Y.-Y.; Zeng, Y.-T.; Su, J.-H.; Wen, Z.-H.; Chang, Y.-C.; Sung, P.-J. (2024) Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis.Chem. Pharm. Bull. 72, 1110–1115.
  3. Le, H.-G.; Chen, Y.-S.; Cheng, T.-P.; Tsai, Y.-F.; Chen, P.-J.; Cheng, W.-C.; El-Shazly, M.; Chang, Y.-C.; Hwang, T.-L. Lai, K-H. (2024) Exploring anti-inflammatory non-essential oil metabolites in Mentha canadensis: Insights into neutrophil extracellular trap inhibition for functional health promotion. Journal of Functional Foods 117, 106233.
  4. Lee T.-H.; Chen, J.-L.; Chang, C.-H.; Tsai, M.-M.; Tseng, H.-C.; Chang, Y.-C.; Shanmugam V.; Hsieh, H.-L. (2024) A Brain-Protective Sterol from Soft Coral Inhibits Lipopolysaccharide-Induced Matrix Metalloproteinase-9-Mediated Astrocytic Migration. Biomedicines 12(1), 226.
  5. Hsieh, H.-L. † ; Yu, M.-C. † ; Chang, Y.-C.; Wu, Y.-H.; Huang, K.-H.; Tsai, M.-M. (2024) Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9. Curr. Issues Mol. Biol. 46(7), 7303-7323.
  6. Hsieh, Y.-H.; Liu, Y.-W.; Chien, S.-Y.; Lin, Y.-C.; Wu, Y.-J.; Su, J.-H.; Liaw, C.-C.; Tsai, Y.-C.; Chang, Y.-C.; Sung, P.-J. (2023). S-cis-Δ 3(E),5(16) -conjugated diene briaranes from the octocoral Junceella fragilis. Tetrahedron, 145, 133626.
  7. Wang, L.-S.; Chen, P.-J ; Cheng, W.-C ; Chang, Y.-C.; El-Shazly, M.; Chen, L. Y.; Peng, B.-R.; Su, C.-H.; Yen, P.-T.; Hwang, T.-L; Lai, K-H. (2023, Mar). Chemometric-guided chemical marker selection: A case study of the heat-clearing herb Scrophularia ningpoensis. Front. Plant Sci. 14:1153710.
  8. Lin, H.-Y.; Chung, C.-P.; Hsia, S.-M.; Chang, Y.-C.; Chiang, W.; Kuo, Y.-H.; Lin, Y.-L. (2023, Feb.). Anti-inflammatory alkaloids from lotus (Nelumbo nucifera Gaertn.) leaves. European Food Research and Technology, 249,739–748.
  9. Chen, Y.-L.; Chen, C.-Y.; Lai, K-H.; Chang, Y.-C.; Hwang, T.-L (2023, Jan.) Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19. Journal of Functional Foods 101, 105407.
  10. Lai, K.-H.; Chen, Y.-L.; Lin, M.-F.; El-Shazly, M.; Chang, Y.-C.; Chen, P.-J.; Su, C.-H.; Chiu, T.-C.; Illias, A. M.;, Chen, C.-C.; Chen, L.-Y.; Hwang, T.-L. (2022) Loniceraae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress. Antioxidants, 11, 1781
  11. Kuo, F.-W.; Chang, Y.-C.; Li, H.-H. (2022) Water-insoluble black pigment released from the octocoral Sinularia flexibilis. Appl. Sci. 2022, 12(16), 8012.
  12. Su, C.-H.; Cheng, Y.-C.; Chang, Y.-C.; Kung, T.-H.; Chen, Y.-L.; 4. Lai, K.-H.; Hsieh, H.-L.; Chen, C.-Y.; Hwang, T.-L.; Yang, Y.-L. (2022) Untargeted LC-MS/MS-based multi-informative molecular networking for targeting the antiproliferative ingredients in Tetradium ruticarpum Fruit. Molecules, 27(14), 4462.
  13. Phan, G.-H.; Tsai, Y.-C.; Liu, Y.-H.; Fang, L.-S.; Wen, Z.-H.; Hwang, T.-L.; Chang, Y.-C.*; Sung, P.-J.* (2021) Sterol constituents from a cultured octocoral Sinularia sandensis (Verseveldt 1977). J. Mol. Struc., 1246, 131175. 本人為通訊作者
  14. Kumar, S.; Wang, Y.-H.; Chen, P.-J.; Chang, Y.-C.; Kashyap, H K.; Shen, Y.-C.; Yu, H.-P.; Hwang, T.-L. (2021) Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents. Bioorg.Chem., 111, 104846.
  15. Lai, K.-H.; Chen, C.-C.; El-Shazly, M.; Wu, Y.-H.; Chen, P.-J.; Wu, Y.-H.; Hsieh, H.-L.; Wang, Y.-H.; Chang, Y.-C.; Hwang, T.-L. (2021) Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. J. Ethnopharmacol. 264, 113224.
  16. Chang, Y.-C. † ; Chiang, C.-C. † ; Chang, Y.-S.; Chen, J.-J.-; Wang, W.-H.; Fang, L.-S.; Chung, H.-M.; Hwang, T.-L.; Sung, P.-J. (2020) Novel Caryophyllane‐Related Sesquiterpenoids with Anti‐Inflammatory Activity from Rumphella antipathes (Linnaeus, 1758) Mar. Drugs, 18, 554.
  17. Kumar, S.; Chang, Y.-C.; Lai, K.-H.; Hwang, T.-L. (2020) Resveratrol, a molecule with anti-inflammatory and anti-cancer activities: journey from natural product to chemical synthesis. Curr. Med. Chem. 27, 1–14
  18. Chen, Y.-H.; Chang, Y.-C.; Chen, Y.-H.; Zheng, L.-G.; Huang, P.-C.; Huynh, T.-H.; Peng, B.-R.; Chen, Y.-Y.; Wu, Y.-J.; Fang, L.-S.; Su, J.-H.; Hsu, C.-M.; Sung, P.-J. (2020) Natural Products from Octocorals of the Genus Dendronephthya (Family Nephtheidae) Molecules, 25, 5957.
  19. Chen, P.-J.; Kuo, L.-M.; Wu, Y.-H.; Chang, Y.-C.; Lai, K.-H.; Hwang, T.-L. (2020) BAY 41-2272 attenuates CTGF expression via Akt-dependent but sGC/cGMP-independent pathway in TGFβ1-activated hepatic stellate cells. Biomedicines, 8(9), 330.
  20. Peng, B.-R.; Lai, K.-H.; Chang, Y.-C.; Chen, Y.-Y.; Su, J.-H.; Huang, Y. M.; Chen, P.-J.; Yu, Steve S.-F.; Duh, C.-Y.; Sung, P.-J. (2020) Sponge-derived 24-Homoscalaranes as Potent Anti-inflammatory Agents. Mar. Drugs, 18(9), 434.
  21. Chang, Y.-C.; Lai, K.-H.; Kumar, S.; Chen, P.-J.; Wu, Y.-H.; Lai, C.-L.; Hsieh, H.-L.; Sung, P.-J.; Hwang, T.-L. (2020) 1 H NMR-based isolation of anti-inflammatory 9,11-secosteroids from the octocoral Sinularia leptoclados. Mar. Drugs, 18(5), 271.
  22. Hu, C.-C.; Lin, N.-C.; Peng, B.-R.; Chen, Y.-Y.; Wen, Z.-H.; Chang, Y.-C.; Lee, G.-H.; Wu, Y.-C.; Sung, P.-J. (2020) New trihydroxybriarane diterpenoids from an octocoral Briareum sp. Phytochem. Lett. 35, 23–27.
個人學術研究 / Academic Research
 

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