張祐嘉 助理研究員

吳依璇 (Yi-Hsuan Wu)

職稱：博士後研究員

學歷： 長庚大學生物醫學研究所博士

分機號碼：5230 

電子郵件帳號：yhwu03@mail.cgust.edu.tw

研究專長： 自由基生物學(Redox biology)、免疫學(Immunology)、病毒感染與宿主反應(Virus and host interaction)、表觀遺傳學(Epigenetics)

研究室：中草藥研究中心細胞功能評估平台

研究方向：

miRNA所參與細胞氧化還原反應和SLE發病機理的分子機制

論文著作：

*: first, co-first author.

  1. Lai KH, Chen PJ, Chen CC, Yang SH, El-Shazly M, Chang YC, Wu YH, Wu YH,     Wang YH, Hsieh HL, Hwang TL. Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. J Ethnopharmacol. 2020 Aug 12;264:113224.

  1. Chang YC, Lai KH, Kumar S, Chen PJ, Wu YH, Lai CL, Hsieh HL, Sung PJ, Hwang TL. 1 H NMR-Based Isolation of Anti-Inflammatory 9,11-Secosteroids from the Octocoral Sinularia leptoclados. Mar Drugs. 2020 May 21;18(5):271.

  1. Yen WC, *Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Chiu DT. Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling. Redox Biol. 2020 Jan;28:101363.

  1. Yang HC, *Wu YH, Yen WC, Liu HY, Hwang TL, Stern A, Chiu DT. The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer. Cells. 2019 Sep 8;8(9). Review

  1. *Wu YH, Lee YH, Shih HY, Chen SH, Cheng YC, Chiu DT. Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death Dis. 2018   Jan 9;9(1):10.

  1. *Wu YH, Lin HR, Lee YH, Huang PH, Wei HC, Stern A, Chiu DT. A Novel Fine Tuning Scheme of miR-200c in Modulating Lung Cell Redox Homeostasis. Free Radic Res. 2017 Jun;51(6):591-603

  1. Yang HC, *Wu YH, Liu HY, Stern A, Chiu DT. What has passed is prologue: New cellular and physiological roles of G6PD. Free Radic Res. 2016 Oct 19:1-18. Review

  1. Lin HR, *Wu YH, Yen WC, Yang CM, Chiu DT. Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells. PLoS One. 2016 Apr 20;11(4):e0153462.

  1. *Wu YH, Chiu DT, Lin HR, Tang HY, Cheng ML, Ho HY. Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses. 2015 Dec 17;7(12):6689-706.

  1. Yang HC, Cheng ML, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY, Chiu DT. Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway. J Inflamm (Lond). 2015 Apr 24;12:34.

  1. Lin HR, Wu CC, Wu YH, Hsu CW, Cheng ML, Chiu DT. Proteome-wide dysregulation by glucose-6-phosphate dehydrogenase (G6PD) reveals a novel protective role for G6PD in aflatoxin B₁-mediated cytotoxicity. J Proteome Res. 2013 Jul 5;12(7):3434-48.

  1. Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY, Lo SJ, Chiu DT. Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death Dis. 2013 May 2;4:e616.

  1. *Wu YH, Cheng ML, Ho HY, Chiu DT, Wang TC. Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. J Biomed Sci. 2009 Feb 5;16:18.

  1. *Wu YH, Tseng CP, Cheng ML, Ho HY, Shih SR, Chiu DT. Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection. J Infect Dis. 2008 Mar 15;197(6):812-6.

  1. Cheng ML, Ho HY, Wu YH, Chiu DT. Glucose-6-phosphate dehydrogenase-deficient cells show an increased propensity for oxidant-induced senescence. Free Radic Biol Med. 2004 Mar 1;36(5):580-91.

會議論文：
  1. Experimental Biology 2020; San Diego, USA. April 4-7, 2020. " Upregulation of miR-210-5p in Systemic Lupus Erythematosus Impairs Silent Clearance of Dead Cell Remnants", ePoster.

  1. International Symposium on Redox Biology and Mitochondrial Medicine and 2016 Cross-Strait Free Radical Symposium; Taiwan. 2016/10/21-10/22. "Knockdown of glucose-6-phosphate dehydrogenase inhibits the expression of E-cadherin and impairs zebrafish embryogenesis via NOX/SMAD3/miR-200b/ZEB1 axis", Poster talk.

  1. Experimental Biology 2016; San Diego, USA. 2016/4/2-4/06. "Knockdown Glucose-6-Phosphate Dehydrogenase promotes EMT through downregulation of E-cadherin by miR-200b inhibition in A549 cells ", Oral presentation. 

  1. The 21th annual meeting of The Society for Redox Biology and Medicine (SFRBM 2014); Seattle, USA. 2014/11/19-11/23. "Regulation of Heme Oxygenased-1 Expression by miR-200c upon H2O2 Treatment in A549 Cells", Poster Talk.

  1. 2013 IUBMB conference; Marrakech, Morocco. 2013/11/17-11/20. "Impaired redox signaling and antiviral response against coronaviral infection in G6PD-knockdown epithelial cells", Poster Talk. Supported by TSBMB.

  1. Experimental Biology 2013; Boston, USA. 2013/4/20-4/24."Impaired antiviral response due to up-regulated HSCARG and down-regulated NF-κB signaling by HCoV 229E infection in G6PD-knockdown A549 cells", Poster Talk. Supported by NHRI.

  1. The 13th annual meeting of Society of Chinese Bioscientists in America (SCBA) symposium; 2011/7/25-7/29. "Impaired antiviral response by G6PD Knockdown under early stage of HCoV 229E infection", Poster Talk.  

  1. Experimental Biology 2007; Washington DC, USA. 2007/4/28-5/2. "G6PD Deficiency Enhances Human Coronavirus 229E Infection", Poster Talk.